Recombinant Pseudomonas aeruginosa Protease LasA (lasA)
Recombinant Pseudomonas aeruginosa Protease LasA (lasA)
规格:
货期:
编号:TSANTI000634
品牌:Testobio
| 产品名称: | Recombinant Pseudomonas aeruginosa Protease LasA (lasA) |
| 货号: | TSANTI000634 |
| 纯度： | Greater than 90% as determined by SDS-PAGE. |
| 基因名： | lasA |
| Uniprot No.： | P14789 |
| 别名： | lasA; PA1871Protease LasA; EC 3.4.24.-; Staphylolytic protease |
| 种属： | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) |
| 蛋白长度： | Full Length of Mature Protein |
| 来源： | E.coli |
| 分子量： | 36.0kDa |
| 表达区域： | 237-418aa |
| 氨基酸序列 | APPSNLMQLPWRQGYSWQPNGAHSNTGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSRCQVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYAGNINTALCEGGSSTGPHLHFSLLYNGAFVSLQGASFGPYRINVGTSNYDNDCRRYYFYNQSAGTTHCAFRPLYNPGLAL |
| 蛋白标签： | N-terminal 6xHis-SUMO-tagged |
| 产品提供形式： | Liquid or Lyophilized powder |
| 缓冲液： | Tris-based buffer,50% glycerol |
| 储存条件： | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| 保质期： | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
| 货期： | 3-7 business days |
| 注意事项： | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Datasheet & COA： | Please contact us to get it. |
| 功能： | Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate. |
| 基因功能参考文献： | crystal structures of active LasA as a complex with tartrate and in the uncomplexed form. While the overall fold resembles that of the other M23 family members, the LasA active site is less constricted and utilizes a different set of metal ligands. PMID: 20026068 |
| 亚细胞定位： | Secreted. |
| 蛋白家族： | Peptidase M23A family |
| 数据库链接： | KEGG: pae:PA1871 |
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Recombinant Pseudomonas aeruginosa Protease LasA (lasA)
Recombinant Pseudomonas aeruginosa Protease LasA (lasA)
规格:
货期:
编号:TSANTI000634
品牌:Testobio
| 产品名称: | Recombinant Pseudomonas aeruginosa Protease LasA (lasA) |
| 货号: | TSANTI000634 |
| 纯度： | Greater than 90% as determined by SDS-PAGE. |
| 基因名： | lasA |
| Uniprot No.： | P14789 |
| 别名： | lasA; PA1871Protease LasA; EC 3.4.24.-; Staphylolytic protease |
| 种属： | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) |
| 蛋白长度： | Full Length of Mature Protein |
| 来源： | E.coli |
| 分子量： | 36.0kDa |
| 表达区域： | 237-418aa |
| 氨基酸序列 | APPSNLMQLPWRQGYSWQPNGAHSNTGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSRCQVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYAGNINTALCEGGSSTGPHLHFSLLYNGAFVSLQGASFGPYRINVGTSNYDNDCRRYYFYNQSAGTTHCAFRPLYNPGLAL |
| 蛋白标签： | N-terminal 6xHis-SUMO-tagged |
| 产品提供形式： | Liquid or Lyophilized powder |
| 缓冲液： | Tris-based buffer,50% glycerol |
| 储存条件： | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| 保质期： | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
| 货期： | 3-7 business days |
| 注意事项： | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Datasheet & COA： | Please contact us to get it. |
| 功能： | Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate. |
| 基因功能参考文献： | crystal structures of active LasA as a complex with tartrate and in the uncomplexed form. While the overall fold resembles that of the other M23 family members, the LasA active site is less constricted and utilizes a different set of metal ligands. PMID: 20026068 |
| 亚细胞定位： | Secreted. |
| 蛋白家族： | Peptidase M23A family |
| 数据库链接： | KEGG: pae:PA1871 |