Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1)
Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1)
规格:
货期:
编号:TSANTI000647
品牌:Testobio
| 产品名称: | Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1) |
| 货号: | TSANTI000647 |
| 纯度： | Greater than 90% as determined by SDS-PAGE. |
| 基因名： | PNC1 |
| Uniprot No.： | P53184 |
| 别名： | PNC1; YGL037C; Nicotinamidase; EC 3.5.1.19; Nicotinamide deamidase; NAMase |
| 种属： | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) |
| 蛋白长度： | Full Length |
| 来源： | E.coli |
| 分子量： | 29.0kDa |
| 表达区域： | 1-216aa |
| 氨基酸序列 | MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK |
| 蛋白标签： | N-terminal 6xHis-tagged |
| 产品提供形式： | Liquid or Lyophilized powder |
| 缓冲液： | Tris-based buffer,50% glycerol |
| 储存条件： | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| 保质期： | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
| 货期： | 3-7 business days |
| 注意事项： | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Datasheet & COA： | Please contact us to get it. |
| 功能： | Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate. |
| 基因功能参考文献： | Enhanced resistance was also independent of the nicotinamide salvage pathway, which uses nicotinamide as a substrate to generate NAD+, and of a DNA damage-induced increase in the salvage enzyme Pnc1 PMID: 27527516 |
| 亚细胞定位： | Cytoplasm. Nucleus. Peroxisome. |
| 蛋白家族： | Isochorismatase family |
| 数据库链接： | KEGG: sce:YGL037C |
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Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1)
Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1)
规格:
货期:
编号:TSANTI000647
品牌:Testobio
| 产品名称: | Recombinant Saccharomyces cerevisiae Nicotinamidase (PNC1) |
| 货号: | TSANTI000647 |
| 纯度： | Greater than 90% as determined by SDS-PAGE. |
| 基因名： | PNC1 |
| Uniprot No.： | P53184 |
| 别名： | PNC1; YGL037C; Nicotinamidase; EC 3.5.1.19; Nicotinamide deamidase; NAMase |
| 种属： | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) |
| 蛋白长度： | Full Length |
| 来源： | E.coli |
| 分子量： | 29.0kDa |
| 表达区域： | 1-216aa |
| 氨基酸序列 | MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK |
| 蛋白标签： | N-terminal 6xHis-tagged |
| 产品提供形式： | Liquid or Lyophilized powder |
| 缓冲液： | Tris-based buffer,50% glycerol |
| 储存条件： | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| 保质期： | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
| 货期： | 3-7 business days |
| 注意事项： | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Datasheet & COA： | Please contact us to get it. |
| 功能： | Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate. |
| 基因功能参考文献： | Enhanced resistance was also independent of the nicotinamide salvage pathway, which uses nicotinamide as a substrate to generate NAD+, and of a DNA damage-induced increase in the salvage enzyme Pnc1 PMID: 27527516 |
| 亚细胞定位： | Cytoplasm. Nucleus. Peroxisome. |
| 蛋白家族： | Isochorismatase family |
| 数据库链接： | KEGG: sce:YGL037C |