产品名称: | Recombinant Candida glabrata Serine/threonine-protein kinase ATG1 (ATG1), partial |
货号: | TSANTI000668 |
纯度: | Greater than 90% as determined by SDS-PAGE. |
基因名: | ATG1 |
Uniprot No.: | Q6FL58 |
别名: | ATG1; CAGL0L06006g; Serine/threonine-protein kinase ATG1; EC 2.7.11.1; Autophagy-related protein 1 |
种属: | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
蛋白长度: | Partial |
来源: | E.coli |
分子量: | 38.4kDa |
表达区域: | 11-312aa |
氨基酸序列 | YVVEKEIGKGSFATVYRGHVTTDPKSHIAVKAVARSKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTTTDFYLVMDYCALGDLTFLIKKRKELENNHPLLQTVFNKYPPPSKEHNGLNRAFVVCYLQQLASALKFLRSKNLVHRDIKPQNLLLATPLTNYRDSKTFHELGYVGIYNLPILKIADFGFARFLPSTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLFEMCCGVPPFTASNHLELFKKIKRAHDEINFPEVCEVEDGLKELICSLLTFDPAKRIGFEEFFNNKIV |
蛋白标签: | N-terminal 6xHis-tagged |
产品提供形式: | Liquid or Lyophilized powder |
缓冲液: | Tris-based buffer,50% glycerol |
储存条件: | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
保质期: | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
货期: | 3-7 business days |
注意事项: | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet & COA: | Please contact us to get it. |
功能: | Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. |
亚细胞定位: | Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. |
蛋白家族: | Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily |
数据库链接: | KEGG: cgr:CAGL0L06006g |
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产品名称: | Recombinant Candida glabrata Serine/threonine-protein kinase ATG1 (ATG1), partial |
货号: | TSANTI000668 |
纯度: | Greater than 90% as determined by SDS-PAGE. |
基因名: | ATG1 |
Uniprot No.: | Q6FL58 |
别名: | ATG1; CAGL0L06006g; Serine/threonine-protein kinase ATG1; EC 2.7.11.1; Autophagy-related protein 1 |
种属: | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
蛋白长度: | Partial |
来源: | E.coli |
分子量: | 38.4kDa |
表达区域: | 11-312aa |
氨基酸序列 | YVVEKEIGKGSFATVYRGHVTTDPKSHIAVKAVARSKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTTTDFYLVMDYCALGDLTFLIKKRKELENNHPLLQTVFNKYPPPSKEHNGLNRAFVVCYLQQLASALKFLRSKNLVHRDIKPQNLLLATPLTNYRDSKTFHELGYVGIYNLPILKIADFGFARFLPSTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVLFEMCCGVPPFTASNHLELFKKIKRAHDEINFPEVCEVEDGLKELICSLLTFDPAKRIGFEEFFNNKIV |
蛋白标签: | N-terminal 6xHis-tagged |
产品提供形式: | Liquid or Lyophilized powder |
缓冲液: | Tris-based buffer,50% glycerol |
储存条件: | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
保质期: | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
货期: | 3-7 business days |
注意事项: | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet & COA: | Please contact us to get it. |
功能: | Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. |
亚细胞定位: | Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. |
蛋白家族: | Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily |
数据库链接: | KEGG: cgr:CAGL0L06006g |