产品名称: | Recombinant Candida glabrata Autophagy-related protein 8 (ATG8) |
货号: | TSANTI000675 |
纯度: | Greater than 90% as determined by SDS-PAGE. |
基因名: | ATG8 |
Uniprot No.: | Q6FXR8 |
别名: | ATG8; AUT7; CAGL0A04675gAutophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8 |
种属: | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
蛋白长度: | Full Length |
来源: | E.coli |
分子量: | 29.5kDa |
表达区域: | 1-116aa |
氨基酸序列 | MKSSFKSEYPFEKRKAESERISEKFQNRIPVICEKAEKSDIPEVDKRKYLVPADLTVGQFVYVIRKRIMLPPEKAIFIFVNDTLPPTASLMSQVYQEHKDKDGFLYVTYSGENTFG |
蛋白标签: | N-terminal 6xHis-SUMO-tagged |
产品提供形式: | Liquid or Lyophilized powder |
缓冲液: | Tris-based buffer,50% glycerol |
储存条件: | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
保质期: | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
货期: | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
注意事项: | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet & COA: | Please contact us to get it. |
功能: | Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. |
亚细胞定位: | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor. |
蛋白家族: | ATG8 family |
数据库链接: | KEGG: cgr:CAGL0A04675g |
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产品名称: | Recombinant Candida glabrata Autophagy-related protein 8 (ATG8) |
货号: | TSANTI000675 |
纯度: | Greater than 90% as determined by SDS-PAGE. |
基因名: | ATG8 |
Uniprot No.: | Q6FXR8 |
别名: | ATG8; AUT7; CAGL0A04675gAutophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8 |
种属: | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
蛋白长度: | Full Length |
来源: | E.coli |
分子量: | 29.5kDa |
表达区域: | 1-116aa |
氨基酸序列 | MKSSFKSEYPFEKRKAESERISEKFQNRIPVICEKAEKSDIPEVDKRKYLVPADLTVGQFVYVIRKRIMLPPEKAIFIFVNDTLPPTASLMSQVYQEHKDKDGFLYVTYSGENTFG |
蛋白标签: | N-terminal 6xHis-SUMO-tagged |
产品提供形式: | Liquid or Lyophilized powder |
缓冲液: | Tris-based buffer,50% glycerol |
储存条件: | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
保质期: | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. |
货期: | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
注意事项: | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Datasheet & COA: | Please contact us to get it. |
功能: | Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. |
亚细胞定位: | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor. |
蛋白家族: | ATG8 family |
数据库链接: | KEGG: cgr:CAGL0A04675g |