通过将pheP和3个stlA拷贝整合到大肠杆菌Nissle染色体中，引入诱导型启动子PfnrS，获得一个能够代谢苯丙酮酸的菌株SYNB1618。
参考文献：Isabella VM, Ha BN, Castillo MJ, Lubkowicz DJ, Rowe SE, Millet YA, Anderson CL, Li N, Fisher AB, West KA, Reeder PJ, Momin MM, Bergeron CG, Guilmain SE, Miller PF, Kurtz CB, Falb D. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat Biotechnol. 2018 Oct;36(9):857-864.
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通过将pheP和3个stlA拷贝整合到大肠杆菌Nissle染色体中，引入诱导型启动子PfnrS，获得一个能够代谢苯丙酮酸的菌株SYNB1618。
参考文献：Isabella VM, Ha BN, Castillo MJ, Lubkowicz DJ, Rowe SE, Millet YA, Anderson CL, Li N, Fisher AB, West KA, Reeder PJ, Momin MM, Bergeron CG, Guilmain SE, Miller PF, Kurtz CB, Falb D. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat Biotechnol. 2018 Oct;36(9):857-864.
