| 产品名称： | Streptomyces peucetius Grein et al. |
|---|---|
| 商品货号： | TS190439 |
| Strain Designations： | IMRU 3868 JCM 9920 |
| Application： | Produces FCE 21424 Produces FCE 24366 Produces FCE 24367 Produces anthracyclines Produces daunorubicin daunomycin Produces antineoplastic agents FCE 21424, FCE 24366 and FCE 24367 |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Preceptrol®： | no |
| Type Strain： | yes (type strain) |
| Comments： | Protease activity Synthase genes for daunorubicin/doxorubicin |
| Medium： | ATCC® Medium 196: Yeast malt extract agar |
| Growth Conditions： | Temperature: 26.0°C |
| Name of Depositor： | RE Gordon |
| Chain of Custody： | ATCC < |
| References： | Dekleva ML, et al. Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium. Can. J. Microbiol. 31: 287-294, 1985. PubMed: 3859358 Cassinelli G, et al. New biosynthetic anthracyclines related to barminomycins incorporating barbiturates in their moiety. J. Antibiot. 43: 19-28, 1990. PubMed: 2307627 Gibb GD, Strohl WR. Physiological regulation of protease activity in Streptomyces peucetius. Can. J. Microbiol. 34: 187-190, 1988. PubMed: 3042115 Stutzman-Engwall KJ, Hutchinson CR. Multigene families for anthracycline antibiotic production in Streptomyces peucetius. Proc. Natl. Acad. Sci. USA 86: 3135-3139, 1989. PubMed: 2717612 Rajgarhia VB, Strohl WR. Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis. J. Bacteriol. 179: 2690-2696, 1997. PubMed: 9098068 Furuya K, Hutchinson CR. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. J. Bacteriol. 178: 6310-6318, 1996. PubMed: 8892835 Lomovskaya N, et al. The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production. J. Bacteriol. 178: 3238-3245, 1996. PubMed: 8655504 Skerman VB, et al. Approved lists of bacterial names. Int J Syst Bacteriol 30: 225-420, 1980. type strain type strain |
| Cross References： | Nucleotide (GenBank) : M80237 S.peucetius DnrI and DnrJ genes, complete cds. Nucleotide (GenBank) : L76359 Streptomyces peucetius daunorubicin resistance protein (drrC) gene, complete cds. Nucleotide (GenBank) : L13453 Streptomyces peucetius (clone pWHM902) carminomycin 4-O-methyltransferase gene, complete cds. Nucleotide (GenBank) : L47164 Streptomyces peucetius dnrP gene, partial cds, glycosyl transferase (dnrS) and dnrQ genes, complete cds. Nucleotide (GenBank) : L35560 Streptomyces peucetius daunorubicin-doxorubicin polyketide synthase (dnrH, dpsA-dpsF) genes, ORF5 and ORF8, complete cds. Nucleotide (GenBank) : L47163 Streptomyces peucetius glucose-1-phosphate thymidylyltransferase (dnrL) gene, complete cds and truncated dnrM gene, complete cds. Nucleotide (GenBank) : U18082 Streptomyces peucetius daunorubicin and doxorubicin resistance determinant (drrAB) gene, partial cds, and aklavinone C-11 hydroxylase (dnrF) gene, complete cds. Nucleotide (GenBank) : L37338 Streptomyces peucetius TDP-D-glucose-4,6-dehydratase (dnrM) gene, 3 end, regulatory protein (dnrN) gene, complete cds, and repressor protein (dnrO) gene, complete cds. Nucleotide (GenBank) : L40425 Streptomyces peucetius methylaklanonic acid cyclase (dnrD), carminomycin o-methyltransferase (dnrK) and 10-carbomethoxy-13-deoxycarminomycin esterase (dnrP) genes, three complete cdss. Nucleotide (GenBank) : AF006633 Streptomyces peucetius daunosamine biosynthesis genes, putative flavoprotein (dnmZ), putative epimerase (dnmU) and thymidine diphospho-4-keto-2,3,6-trideoxyhexulose reductase (dnmV) genes, complete cds. Nucleotide (GenBank) : U77891 Streptomyces peucetius daunorubicin C-14 hydroxylase (doxA), doxorubicin biosynthesis enzyme DnrV (dnrV), daunorubicin C-13 ketoreductase (dnrU), daunorubicin acyl carrier protein (dpsG), daunorubicin biosynthesis enzyme (dpsH), doxorubicin |
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| 产品名称： | Streptomyces peucetius Grein et al. |
|---|---|
| 商品货号： | TS190439 |
| Strain Designations： | IMRU 3868 JCM 9920 |
| Application： | Produces FCE 21424 Produces FCE 24366 Produces FCE 24367 Produces anthracyclines Produces daunorubicin daunomycin Produces antineoplastic agents FCE 21424, FCE 24366 and FCE 24367 |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Preceptrol®： | no |
| Type Strain： | yes (type strain) |
| Comments： | Protease activity Synthase genes for daunorubicin/doxorubicin |
| Medium： | ATCC® Medium 196: Yeast malt extract agar |
| Growth Conditions： | Temperature: 26.0°C |
| Name of Depositor： | RE Gordon |
| Chain of Custody： | ATCC < |
| References： | Dekleva ML, et al. Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium. Can. J. Microbiol. 31: 287-294, 1985. PubMed: 3859358 Cassinelli G, et al. New biosynthetic anthracyclines related to barminomycins incorporating barbiturates in their moiety. J. Antibiot. 43: 19-28, 1990. PubMed: 2307627 Gibb GD, Strohl WR. Physiological regulation of protease activity in Streptomyces peucetius. Can. J. Microbiol. 34: 187-190, 1988. PubMed: 3042115 Stutzman-Engwall KJ, Hutchinson CR. Multigene families for anthracycline antibiotic production in Streptomyces peucetius. Proc. Natl. Acad. Sci. USA 86: 3135-3139, 1989. PubMed: 2717612 Rajgarhia VB, Strohl WR. Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis. J. Bacteriol. 179: 2690-2696, 1997. PubMed: 9098068 Furuya K, Hutchinson CR. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. J. Bacteriol. 178: 6310-6318, 1996. PubMed: 8892835 Lomovskaya N, et al. The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production. J. Bacteriol. 178: 3238-3245, 1996. PubMed: 8655504 Skerman VB, et al. Approved lists of bacterial names. Int J Syst Bacteriol 30: 225-420, 1980. type strain type strain |
| Cross References： | Nucleotide (GenBank) : M80237 S.peucetius DnrI and DnrJ genes, complete cds. Nucleotide (GenBank) : L76359 Streptomyces peucetius daunorubicin resistance protein (drrC) gene, complete cds. Nucleotide (GenBank) : L13453 Streptomyces peucetius (clone pWHM902) carminomycin 4-O-methyltransferase gene, complete cds. Nucleotide (GenBank) : L47164 Streptomyces peucetius dnrP gene, partial cds, glycosyl transferase (dnrS) and dnrQ genes, complete cds. Nucleotide (GenBank) : L35560 Streptomyces peucetius daunorubicin-doxorubicin polyketide synthase (dnrH, dpsA-dpsF) genes, ORF5 and ORF8, complete cds. Nucleotide (GenBank) : L47163 Streptomyces peucetius glucose-1-phosphate thymidylyltransferase (dnrL) gene, complete cds and truncated dnrM gene, complete cds. Nucleotide (GenBank) : U18082 Streptomyces peucetius daunorubicin and doxorubicin resistance determinant (drrAB) gene, partial cds, and aklavinone C-11 hydroxylase (dnrF) gene, complete cds. Nucleotide (GenBank) : L37338 Streptomyces peucetius TDP-D-glucose-4,6-dehydratase (dnrM) gene, 3 end, regulatory protein (dnrN) gene, complete cds, and repressor protein (dnrO) gene, complete cds. Nucleotide (GenBank) : L40425 Streptomyces peucetius methylaklanonic acid cyclase (dnrD), carminomycin o-methyltransferase (dnrK) and 10-carbomethoxy-13-deoxycarminomycin esterase (dnrP) genes, three complete cdss. Nucleotide (GenBank) : AF006633 Streptomyces peucetius daunosamine biosynthesis genes, putative flavoprotein (dnmZ), putative epimerase (dnmU) and thymidine diphospho-4-keto-2,3,6-trideoxyhexulose reductase (dnmV) genes, complete cds. Nucleotide (GenBank) : U77891 Streptomyces peucetius daunorubicin C-14 hydroxylase (doxA), doxorubicin biosynthesis enzyme DnrV (dnrV), daunorubicin C-13 ketoreductase (dnrU), daunorubicin acyl carrier protein (dpsG), daunorubicin biosynthesis enzyme (dpsH), doxorubicin |
