| 产品名称： | Cryptococcus neoformans (Sanfelice) Vuillemin |
|---|---|
| 商品货号： | TS204321 |
| Deposited As： | Cryptococcus neoformans (Sanfelice) Vuillemin, anamorph |
| Strain Designations： | C21F3 |
| Alternate State： | Filobasidiella neoformans Kwon-Chung |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | frozen |
| Storage Conditions： | Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section |
| Type Strain： | no |
| Antigenic Properties： | serotype D, serotype D
Ref  Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
| Genotype： | frr1-3
RefCruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
| Preceptrol®： | no |
| Ploidy： | haploid |
| Comments： | rapamycin- and FK506-resistant does not express FKBP12 protein |
| Medium： | ATCC® Medium 1245: YEPD |
| Growth Conditions： | Temperature: 25.0°C |
| Name of Depositor： | J Heitman |
| Special Collection： | NCRR Contract |
| Isolation： | derived from JEC21 (ATCC 96910) |
| References： | Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob. Agents Chemother. 41: 156-161, 1997. PubMed: 8980772 Odom A, et al. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576-2589, 1997. PubMed: 9184205 Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
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| 产品名称： | Cryptococcus neoformans (Sanfelice) Vuillemin |
|---|---|
| 商品货号： | TS204321 |
| Deposited As： | Cryptococcus neoformans (Sanfelice) Vuillemin, anamorph |
| Strain Designations： | C21F3 |
| Alternate State： | Filobasidiella neoformans Kwon-Chung |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | frozen |
| Storage Conditions： | Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section |
| Type Strain： | no |
| Antigenic Properties： | serotype D, serotype D
RefCruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
| Genotype： | frr1-3
RefCruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
| Preceptrol®： | no |
| Ploidy： | haploid |
| Comments： | rapamycin- and FK506-resistant does not express FKBP12 protein |
| Medium： | ATCC® Medium 1245: YEPD |
| Growth Conditions： | Temperature: 25.0°C |
| Name of Depositor： | J Heitman |
| Special Collection： | NCRR Contract |
| Isolation： | derived from JEC21 (ATCC 96910) |
| References： | Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob. Agents Chemother. 41: 156-161, 1997. PubMed: 8980772 Odom A, et al. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16: 2576-2589, 1997. PubMed: 9184205 Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 Cruz MC, et al. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 19: 4101-4112, 1999. PubMed: 10330150 |
