| 产品名称： | Rhizopus stolonifer (Ehrenberg : Fries) Lind |
|---|---|
| 商品货号： | TS209342 |
| Deposited As： | Rhizopus nigricans Ehrenberg, teleomorph |
| Strain Designations： | C-25B CBS 382.52, IFO 5781, IFO 6154, IFO 6300, IMI 57762, VKM F-401 |
| Application： | produces 11-alpha-hydroxylase produces 17 beta-hydroxysteroid dehydrogenase Estradiol 17-beta-dehydrogenase-1, Hydroxysteroid dehydrogenase 17 beta, type 1, hydroxysteroid 17-beta dehydrogenase 1 produces chiral alcohols produces steroids transformation of sesquiterpene lactone costunolide reduces 3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraene-14,17-dione |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Type Strain： | no |
| Disclosure： | This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC. |
| Preceptrol®： | no |
| Mating Type： | mating type plus |
| Comments： | Hydroxylation of 17 alpha-ethynyl steroids Detoxification of steroids by cytochrome P45011alpha |
| Medium： | ATCC® Medium 336: Potato dextrose agar (PDA) |
| Growth Conditions： | Temperature: 24.0°C |
| Name of Depositor： | AF Blakeslee |
| Cross References： | Nucleotide (GenBank) : Y10414 R.nigricans mRNA for stress protein. Nucleotide (GenBank) : S50228 steroid hydroxylase cytochrome P-450 Rhizopus nigricans, ATCC |
| References： | Abul-Hajj YJ. Stereochemistry of C-1, 2 dehydrogenation of 5 beta-pregnane-3, 11, 20-trione by Septomyxa affinis. J. Biol. Chem. 247: 686-691, 1972. PubMed: 5058221 Zakelj-Mavric M, et al. The bioconversion of 17 alpha-ethynyl steroids with 11 alpha-hydroxylase of Rhizopus nigricans. FEMS Microbiol. Lett. 33: 117-120, 1986. Mills JS. 10-Fluoro-19-nor steroids. US Patent 3,053,858 dated Sep 11 1962 Gibian H, et al. Production of optically active antipodes. US Patent 3,562,112 dated Feb 9 1971 Lanisnik T, et al. Fungal 17 beta-hydroxysteroid dehydrogenase. FEMS Microbiol. Lett. 78: 49-52, 1992. PubMed: 1334892 Breskvar K, et al. The role of cytochrome P450(11 alpha) in detoxification of steroids in the filamentous fungus Rhizopus nigricans. J. Steroid Biochem. Mol. Biol. 52: 271-275, 1995. PubMed: 7696148 Hudnik-Plevnik T, Cresnar B. Factors affecting the induction of 11 alpha-hydroxylase of progesterone in the filamentous fungus Rhizopus nigricans. J. Steroid Biochem. 35: 749-751, 1990. PubMed: 2362437 Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979. Kasai M, et al. Enantioselective ester hydrolyses using Rhizopus nigricans: stereoselective synthesis and absolute stereochemistry of (-)-cis-and (-)-trans-1-hydroxy-4-methyl-1,2,3,4-tetrahydronaphthalene. Can. J. Chem. 63: 1287-1291, 1985. Zakelj-Mavric M, Belic I. Hydroxylation of steroids with 11alpha-hydroxylase of Rhizopus nigricans. J. Steroid Biochem. 28: 197-201, 1987. PubMed: 3498094 |
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| 产品名称： | Rhizopus stolonifer (Ehrenberg : Fries) Lind |
|---|---|
| 商品货号： | TS209342 |
| Deposited As： | Rhizopus nigricans Ehrenberg, teleomorph |
| Strain Designations： | C-25B CBS 382.52, IFO 5781, IFO 6154, IFO 6300, IMI 57762, VKM F-401 |
| Application： | produces 11-alpha-hydroxylase produces 17 beta-hydroxysteroid dehydrogenase Estradiol 17-beta-dehydrogenase-1, Hydroxysteroid dehydrogenase 17 beta, type 1, hydroxysteroid 17-beta dehydrogenase 1 produces chiral alcohols produces steroids transformation of sesquiterpene lactone costunolide reduces 3-methoxy-8(14)-seco-1,3,5(10),9(11)-estratetraene-14,17-dione |
| Biosafety Level： | 1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format： | freeze-dried |
| Type Strain： | no |
| Disclosure： | This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC. |
| Preceptrol®： | no |
| Mating Type： | mating type plus |
| Comments： | Hydroxylation of 17 alpha-ethynyl steroids Detoxification of steroids by cytochrome P45011alpha |
| Medium： | ATCC® Medium 336: Potato dextrose agar (PDA) |
| Growth Conditions： | Temperature: 24.0°C |
| Name of Depositor： | AF Blakeslee |
| Cross References： | Nucleotide (GenBank) : Y10414 R.nigricans mRNA for stress protein. Nucleotide (GenBank) : S50228 steroid hydroxylase cytochrome P-450 Rhizopus nigricans, ATCC |
| References： | Abul-Hajj YJ. Stereochemistry of C-1, 2 dehydrogenation of 5 beta-pregnane-3, 11, 20-trione by Septomyxa affinis. J. Biol. Chem. 247: 686-691, 1972. PubMed: 5058221 Zakelj-Mavric M, et al. The bioconversion of 17 alpha-ethynyl steroids with 11 alpha-hydroxylase of Rhizopus nigricans. FEMS Microbiol. Lett. 33: 117-120, 1986. Mills JS. 10-Fluoro-19-nor steroids. US Patent 3,053,858 dated Sep 11 1962 Gibian H, et al. Production of optically active antipodes. US Patent 3,562,112 dated Feb 9 1971 Lanisnik T, et al. Fungal 17 beta-hydroxysteroid dehydrogenase. FEMS Microbiol. Lett. 78: 49-52, 1992. PubMed: 1334892 Breskvar K, et al. The role of cytochrome P450(11 alpha) in detoxification of steroids in the filamentous fungus Rhizopus nigricans. J. Steroid Biochem. Mol. Biol. 52: 271-275, 1995. PubMed: 7696148 Hudnik-Plevnik T, Cresnar B. Factors affecting the induction of 11 alpha-hydroxylase of progesterone in the filamentous fungus Rhizopus nigricans. J. Steroid Biochem. 35: 749-751, 1990. PubMed: 2362437 Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979. Kasai M, et al. Enantioselective ester hydrolyses using Rhizopus nigricans: stereoselective synthesis and absolute stereochemistry of (-)-cis-and (-)-trans-1-hydroxy-4-methyl-1,2,3,4-tetrahydronaphthalene. Can. J. Chem. 63: 1287-1291, 1985. Zakelj-Mavric M, Belic I. Hydroxylation of steroids with 11alpha-hydroxylase of Rhizopus nigricans. J. Steroid Biochem. 28: 197-201, 1987. PubMed: 3498094 |
