| NCIMB number | NCIMB 12785 |
| Deposit type | Bacteria |
| Type strain | Yes |
| GMO | No |
| Taxon name | Streptomyces clavuligerus |
| Preservation method | Unknown |
| Price band | A |
| Media | 029 |
| Gas regime | aerobic |
| Growth factors (and/or information) | Bennetts, 25C, 1m: good growth |
| ACDP category | 1 |
| Colony Edge | Fimbriate |
| Colony Surface | Sporing |
| Colony Shape | Irregular |
| Colony Elevation | Flat |
| Colony Colour | White (Spores) |
| Colony Opacity | Opaque |
| Cellular Shape | Filamentous |
| Cellular Motility | No |
| Gram stain | Gram Positive |
| Depositor Company | Japanese Collection of Microorganisms (JCM) |
| Depositor Address | Hirosawa, Wako-shi Saitama 351-01 Japan |
| Source | "Soil, South America" |
| Date of Accession | 28/09/1988 |
| History | KCC -- MCRL -- NRRL -- Eli Lilly and Company |
| Other collection IDs | ATCC27064 CBS226.75 DSM738 DSM40751 DSM41253 IFO13307 IMET43657 JCM4710 KCCS-0710 MCRL0774 NRRL3585 |
| Yeast? | False |
| K12 | No |
| References | Higgens C.E. and Kastner R.E. (1971) Int. J. syst. Bact. 21 pp326-331 IJSEM (2002) 52:1632 Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952; Res Microbiol 156(5-6), 707-712, 2005; , 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus; Antimicrob Agents Chemother 56(9), 4845-4855, 2012; , 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus; Chem Biol 14(2), 131-142, 2007; , A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production; J Ind Microbiol Biotechnol 36(2), 301-311, 2009; , A two-component regulatory system involved in clavulanic acid production; J Antibiot (Tokyo) 61(11), 651-659, 2008; , Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation; Mol Microbiol 54(4), 1022-1035, 2004; , An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.; Mol Microbiol 61(3), 758-770, 2006; , Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus; Res Microbiol 157(6), 559-568, 2006; , Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585; Biochim Biophys Acta 1522(2), 112-117, 2001; , Coenzyme B12 controls transcription of the Streptomyces class Ia ribonucleotide reductase nrdABS operon via a riboswitch mechanism; J Bacteriol 188(7), 2512-2520, 2006; , Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production; Mol Microbiol 66(2), 511-524, 2007; , Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit; J Bacteriol 181(22), 6922-6928, 1999; , Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus; Mol Microbiol 56(3), 824-835, 2005; , Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites; J Bacteriol 192(23), 6317-6318, 2010; , Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus; Antimicrob Agents Chemother 44(3), 720-726, 2000; , Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus; J Bacteriol 182(14), 4087-4095, 2000; , Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG; Antimicrob Agents Chemother 49(4), 1529-1541, 2005; , Glycerol utilization gene cluster in Streptomyces clavuligerus; Appl Environ Microbiol 75(9), 2991-2995, 2009; , Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp; Microbiology (Reading, Engl) 154(Pt 3), 744-755, 2008; , Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth; Microbiology 148(2), 391-404, 2002; , The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene; Microbiology (Reading, Engl) 156(5), 1527-1537, 2010; , The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant; Microbiology 148(3), 643-656, 2002; , The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways; Genome Biol Evol 2, 212-224, 2010; , The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons.; J Bacteriol 188(21), 7635-7644, 2006; , Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus; Microbiology 150(5), 1485-1493, 2004; , |
| NCIMB number | NCIMB 12785 |
| Deposit type | Bacteria |
| Type strain | Yes |
| GMO | No |
| Taxon name | Streptomyces clavuligerus |
| Preservation method | Unknown |
| Price band | A |
| Media | 029 |
| Gas regime | aerobic |
| Growth factors (and/or information) | Bennetts, 25C, 1m: good growth |
| ACDP category | 1 |
| Colony Edge | Fimbriate |
| Colony Surface | Sporing |
| Colony Shape | Irregular |
| Colony Elevation | Flat |
| Colony Colour | White (Spores) |
| Colony Opacity | Opaque |
| Cellular Shape | Filamentous |
| Cellular Motility | No |
| Gram stain | Gram Positive |
| Depositor Company | Japanese Collection of Microorganisms (JCM) |
| Depositor Address | Hirosawa, Wako-shi Saitama 351-01 Japan |
| Source | "Soil, South America" |
| Date of Accession | 28/09/1988 |
| History | KCC -- MCRL -- NRRL -- Eli Lilly and Company |
| Other collection IDs | ATCC27064 CBS226.75 DSM738 DSM40751 DSM41253 IFO13307 IMET43657 JCM4710 KCCS-0710 MCRL0774 NRRL3585 |
| Yeast? | False |
| K12 | No |
| References | Higgens C.E. and Kastner R.E. (1971) Int. J. syst. Bact. 21 pp326-331 IJSEM (2002) 52:1632 Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952; Res Microbiol 156(5-6), 707-712, 2005; , 5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus; Antimicrob Agents Chemother 56(9), 4845-4855, 2012; , 5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus; Chem Biol 14(2), 131-142, 2007; , A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production; J Ind Microbiol Biotechnol 36(2), 301-311, 2009; , A two-component regulatory system involved in clavulanic acid production; J Antibiot (Tokyo) 61(11), 651-659, 2008; , Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation; Mol Microbiol 54(4), 1022-1035, 2004; , An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.; Mol Microbiol 61(3), 758-770, 2006; , Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus; Res Microbiol 157(6), 559-568, 2006; , Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585; Biochim Biophys Acta 1522(2), 112-117, 2001; , Coenzyme B12 controls transcription of the Streptomyces class Ia ribonucleotide reductase nrdABS operon via a riboswitch mechanism; J Bacteriol 188(7), 2512-2520, 2006; , Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production; Mol Microbiol 66(2), 511-524, 2007; , Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit; J Bacteriol 181(22), 6922-6928, 1999; , Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus; Mol Microbiol 56(3), 824-835, 2005; , Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites; J Bacteriol 192(23), 6317-6318, 2010; , Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus; Antimicrob Agents Chemother 44(3), 720-726, 2000; , Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus; J Bacteriol 182(14), 4087-4095, 2000; , Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG; Antimicrob Agents Chemother 49(4), 1529-1541, 2005; , Glycerol utilization gene cluster in Streptomyces clavuligerus; Appl Environ Microbiol 75(9), 2991-2995, 2009; , Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp; Microbiology (Reading, Engl) 154(Pt 3), 744-755, 2008; , Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth; Microbiology 148(2), 391-404, 2002; , The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene; Microbiology (Reading, Engl) 156(5), 1527-1537, 2010; , The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant; Microbiology 148(3), 643-656, 2002; , The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways; Genome Biol Evol 2, 212-224, 2010; , The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons.; J Bacteriol 188(21), 7635-7644, 2006; , Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus; Microbiology 150(5), 1485-1493, 2004; , |