1、菌株名称：Rothia mucilaginosa 胺胨罗斯氏菌
3、其他中心编号：ATCC 25296=GIFU 9911=CCM 2417=CCUG 20962=DSM 20746=JCM 10910=NCTC 10663
4、分离源：人的咽部
冻千菌种应在2~8°C保存。活化好的菌种应保藏于清洁和干燥的地方,置于室温光照保存。
1、培养基：NBRC #802: 多聚蛋白栋 10.0g 酵母粉 2.0g MgSO4·7H2O 1.0g 蒸馏水 1L 琼脂 15.0g
2、培养条件：37℃
1、冻干首次活化应将整支冻干菌种溶解后转接在10-20ml培养液中，培养液应加满至瓶盖处，每天转动位置使光照均匀，但不能强烈摇动，使用的试管应是螺口管并且密封性较好。
2、微生物菌种应保藏低温、清洁和干燥的地方,室温放置时间过长会导致菌种衰退；
3、菌种操作应在无菌条件下进行：转种完毕,废弃物应经灭菌再做丢弃处理,以免污染周围环境；
4、操作前,如果有不明白之处,应先咨询我中心技术人员,避免不必要的损失。
Rothia mucilaginosa (formerly known as Stomatococcus mucilaginosus) is a Gram-positive, coagulase-negative, encapsulated, non-spore-forming and non-motile coccus, present in clusters, tetrads or pairs that is a part of the normal oropharyngeal flora. Belonging to the family Micrococcaceae, it was first isolated from the mucous membrane of the cheek and gingiva. It is an oral commensal, that has been linked to causing severe bacteremia in immunocompromised patients.This bacterium has also been shown to form biofilms, similar to that of Pseudomonas aeruginosa. R. mucilaginosa is a cohabitant in the lower airways of patient with bronchiectasis
Rothia mucilaginosa is a Gram-positive, coagulase-negative, encapsulated, non-spore-forming and non-motile coccus, present in clusters, tetrads or pairs.R. mucilaginosa can easily be confused for the bacteria from the genera Micrococcus and Staphylococcus. One way that it can be distinguished from those two is by its strong adherence to the solid medium substrate that its colonies form. Another way is by its weak or absent catalase reaction, failure to grow on 5% NaCl media or its glucose and sucrose fermentation.
Rothia mucilaginosa has been linked to Bronchiectasis, showing that an inhibition of the COX-2 inhibitor is largely related to an increased production of PGE2, which has been shown to be immunosuppressive in animal models of bacterial pneumonias and sepsis. The inhibition of COX-2 improved survival in mice, suggesting that the pathogenic effects of R. mucilaginosa are related to the induction of COX-2 It is also closely associated with Bacteremia, sepsis, and endocarditis.
Rothia mucilaginosa is resistant to the quinolone class of antibiotics, with extreme resistance to fluoroquinolones. Sensitivity, as of 2003, is still found in trimethoprim-sulfamethoxazole, vancomycin and bacitracin.
